Dr Chris Moxon
Chris' Clinical PhD Programme Experience:
"I wanted to better understand the pathogenesis of cerebral malaria and particularly why the condition targets the brain. Investigating petechiael lesions in the brain I identified a previously unrecognized mechanism involved in cerebral malaria: malaria infected red blood cells remove key endothelial anti-coagulant endothelial protective receptors called endothelial protein C receptor and thrombomodulin. I also developed a novel assay to examine the receptors on the vascular endothelium directly from subcutaneous needle biopsies taken from patients. This tool should enable better understanding of changes in this vital tissue both during disease in malaria and in other conditions.
The Wellcome funded fellowship gave me the opportunity to use state-of-the art scientific techniques to further understanding of a disease in one of the world’s poorest countries. The results of my project have generated considerable interest at international meetings including at the International Society of Thrombosis and Hemostasis meeting - the largest international meeting on coagulation - where the results were presented in the ‘Hot Topic’ session and for which I received a young investigator award.
I have recently been appointed to a Clinical Lectureship in Paediatric infectious diseases at the University of Liverpool. This will enable me to continue clinical training in my chosen specialty whilst also doing post-doctoral research on endothelial biology."
Publications for Chris Moxon
Safety of lumbar puncture in comatose children with clinical features of cerebral malaria
Moxon CA, Zhao L, Li C, Seydel KB, MacCormick IJ, Diggle PJ, Mallewa M, Solomon T, Beare NA, Glover SJ, Harding SP, Lewallen S, Kampondeni S, Potchen MJ, Taylor TE, Postels DG
Laboratory evidence of disseminated intravascular coagulation is associated with a fatal outcome in children with cerebral malaria despite an absence of clinically evident thrombosis or bleeding.
Moxon CA, Chisala NV, Mzikamanda R, MacCormick I, Harding S, Downey C, Molyneux M, Seydel KB, Taylor TE, Heyderman RS, Toh CH
Persistent Endothelial Activation and Inflammation After Plasmodium falciparum Infection in Malawian Children
Christopher A. Moxon, Ngawina V. Chisala, Samuel C. Wassmer, Terrie E. Taylor, Karl B. Seydel, Malcolm E. Molyneux, Brian Faragher, Neil Kennedy, Cheng-Hock Toh, Alister G. Craig, Robert S. Heyderman
Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children
Christopher A. Moxon, Samuel C. Wassmer, Danny A. Milner, Jr, Ngawina V. Chisala, Terrie E. Taylor, Karl B. Seydel, Malcolm E. Molyneux, Brian Faragher, Charles T. Esmon, Colin Downey, Cheng-Hock Toh, Alister G. Craig, Robert S. Heyderman
Vascular endothelial cells cultured from patients with cerebral or uncomplicated malaria exhibit differential reactivity to TNF
Wassmer, S.C., Moxon, C.A., Taylor, T., Grau, G.E., Molyneux, M.E. & Craig, A.G
Malaria: modification of the red blood cell and consequences in the human host
Moxon CA, Grau GE, Craig AG.
Human melioidosis, Malawi, 2011
Thembi Katangwe, Janet Purcell, Naor Bar-Zeev, Brigitte Denis, Jacqui Montgomery, Maaike Alaerts, Robert Simon Heyderman, David A.B. Dance, Neil Kennedy, Nicholas Feasey, Christopher Alan Moxon
Basal enrichment within neuroepithelia suggests novel function(s) for Celsr1 protein.
Formstone CJ, Moxon C, Murdoch J, Little P, Mason I.
Dysregulation of coagulation in cerebral malaria.
Christopher Alan Moxon, Robert Simon Heyderman, Samuel Crocodile Wassmer
|Poster – American Society of Tropical Medicine and Hygeine. 60th Annual meeting 2011 – Travel Award
|Academic Paediatric Association Annual Meeting 19th April 2013 – Prize for best trainee presentation
|‘Hot topic’ speaker for 58th Meeting of the International Society of Thrombosis and Hemostasis, Liverpool 2012 – Young Investigator Award
|Royal Society of Tropical Medicine and Hygiene has awarded a small grant of £4,968 for Aetiology of culture negative presumed bacterial meningitis in neonates and HIV-infected adults in Malawi.
|Invited Speaker. Royal Society of Tropical Medicine and Hygiene Annual Meeting, Warwick 2012. ‘Pathogenesis of Cerebral Malaria in African Children’.