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Dr Standwell Nkhoma

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Dr Standwell Nkhoma is a Malawian scientist with a broad range of research interests in tropical infectious diseases ranging from understanding the basic biology of pathogens and host-pathogen interactions, unraveling the mechanisms of drug resistance to evaluating the impact of disease control programmes. He was a recipient of the four-year Wellcome Trust Intermediate Fellowship in Tropical Medicine and Public Health, and is largely based at the MLW in Blantyre, Malawi. Dr Nkhoma’s project focussed on malaria, a parasitic disease transmitted to human beings through mosquito bites and responsible for over half a million deaths among African children annually. His project aimed                                                                                                                                                                                                                                                                                                                                                                        to characterise the genetic diversity of malaria parasites in patients from an area of intense malaria transmission in Malawi, and evaluate its effect on malaria disease severity and the evolution of antimalarial drug resistance. He will use anewly developed single-cell genomic approaches to characterise within-host diversity of malaria parasites at an unprecedented depth and scale.

Click to watch Standwell talk about the aims for his fellowship


Publications for Standwell Nkhoma

Publication Population Structure Shapes Copy Number Variation in Malaria Parasites.
Cheeseman IH, Miller B, Tan JC, Tan A, Nair S, Nkhoma SC, De Donato M, Rodulfo H, Dondorp A, Branch OH, Mesia LR, Newton P, Mayxay M, Amambua-Ngwa A, Conway DJ, Nosten F1, Ferdig MT, Anderson TJ.

Publication Subtle changes in Plasmodium falciparum infection complexity following enhanced intervention in Malawi.
Sisya TJ, Kamn'gona RM, Vareta JA, Fulakeza JM, Mukaka MF, Seydel KB, Laufer MK, Taylor TE, Nkhoma SC.

Publication Single-cell genomics for dissection of complex malaria infections
Nair, S; Nkhoma, SC; Serre, D; Zimmerman, PA; Gorena, K; Daniel, BJ; Nosten, F; Anderson, TJC; Cheeseman, IH

Publication The role of angiogenic factors in predicting clinical outcome in severe bacterial infection in Malawian children.
Limangeni A Mankhambo, Daniel L Banda, The IPD Study Group, Graham Jeffers, Sarah A White, Paul Balmer, Standwell Nkhoma, Happy Phiri, Elizabeth M Molyneux, C Anthony Hart, Malcolm E Molyneux, Robert S Heyderman, Enitan D Carrol

Publication Defining the in vivo phenotype of artemisinin-resistant falciparum malaria: a modelling approach.

White LJ, Flegg JA, Phyo AP, Wiladpai-ngern JH, Bethell D, Plowe C, Anderson T, Nkhoma S, Nair S, Tripura R, Stepniewska K, Pan-Ngum W, Silamut K, Cooper BS, Lubell Y, Ashley EA, Nguon C, Nosten F, White NJ, Dondorp AM.