Dr Nick Feasey
Nick is a medical microbiologist and infectious disease physician, and was based at the Malawi Liverpool Wellcome Trust Laboratory. His undergraduate training was at the Royal Free and he trained in infection medicine at St George’s Hospital in London. Nick's research interests include invasive Salmonella, the evolution of antimicrobial resistance and Cryptococcal meningitis and he was awarded a Research Training Fellowship by the Wellcome Trust in June 2010.
Nick's research in Malawi focused on causes of and outcomes from bloodstream infection (BSI), especially invasive Salmonella disease. The work demonstrated that a fall in BSI of all causes following the roll-out of antiretroviral therapy, especially recurrent Salmonella BSI. Investigation of the genomic epidemiology of Salmonella Enteritidis at WTSI revealed the existence of a novel, African clone of Enteritidis circulating in Africa.
Publications for Nick Feasey
Rapid emergence of multidrug resistant, H58-lineage Salmonella typhi in Blantyre, Malawi.
Feasey NA, Gaskell K, Wong V, Msefula C, Selemani G, Kumwenda S, Allain TJ, Mallewa J, Kennedy N, Bennett A, Nyirongo JO, Nyondo PA, Zulu MD, Parkhill J, Dougan G, Gordon MA, Heyderman RS.
Patterns of Genome Evolution That Have Accompanied Host Adaptation in Salmonella.
Langridge GC, Fookes M, Connor TR, Feltwell T, Feasey N, Parsons BN, Seth-Smith HM, Barquist L, Stedman A, Humphrey T, Wigley P, Peters SE, Maskell DJ, Corander J, Chabalgoity JA, Barrow P, Parkhill J, Dougan G, Thomson NR.
A prospective study of mortality from cryptococcal meningitis following treatment induction with 1200 mg oral fluconazole in Blantyre, Malawi.
Katherine M. Gaskell, Camilla Rothe, Roshina Gnanadurai, Patrick Goodson, Chikondi Jassi, Robert S. Heyderman, Theresa J. Allain, Thomas S. Harrison, David G. Lalloo, Derek J. Sloan, and Nicholas A. Feasey
Drug resistance in Salmonella enterica ser. Typhimurium bloodstream infection, Malawi.
Feasey NA, Cain AK, Msefula CL, Pickard D, Alaerts M, Aslett M, Everett DB, Allain TJ, Dougan G, Gordon MA, Heyderman RS, Kingsley RA.
A reduction in adult blood stream infection and case fatality at a large African hospital following antiretroviral therapy roll-out.
Feasey NA, Houston A, Mukaka M, Komrower D, Mwalukomo T, Tenthani L, Jahn A, Moore M, Peters RP, Gordon MA, Everett DB, French N, van Oosterhout JJ, Allain TJ, Heyderman RS.
Bacterial meningitis in Malawian adults, adolescents, and children during the era of antiretroviral scale-up and Haemophilus influenzae type b vaccination, 2000-2012.
Wall EC, Everett DB, Mukaka M, Bar-Zeev N, Feasey N, Jahn A, Moore M, van Oosterhout JJ, Pensalo P, Baguimira K, Gordon SB, Molyneux EM, Carrol ED, French N, Molyneux ME, Heyderman RS.
Sequential acquisition of T cells and antibodies to nontyphoidal Salmonella in Malawian children.
Nyirenda TS, Gilchrist JJ, Feasey NA, Glennie SJ, Bar-Zeev N, Gordon MA, MacLennan CA, Mandala WL, Heyderman RS.
Sepsis carries a high mortality among hospitalised adults in Malawi in the era of antiretroviral therapy scale-up: A longitudinal cohort study.
Waitt PI, Mukaka M, Goodson P, SimuKonda FD, Waitt CJ, Feasey N, Allain TJ, Downie P, Heyderman RS3
Evaluation of Xpert MTB/RIF for Detection of Tuberculosis from Blood Samples of HIV-Infected Adults Confirms Mycobacterium tuberculosis Bacteremia as an Indicator of Poor Prognosis
Nicholas A. Feasey, Padmapriya P. Banada, William Howson, Derek J. Sloan, Aaron Mdolo, Catharina Boehme, Geoffrey A. Chipungu, Theresa J. Allain, Robert S. Heyderman, Elizabeth L. Corbett, David Alland
A prospective longitudinal study of the clinical outcomes from cryptococcal meningitis following treatment induction with 800 mg oral fluconazole in Blantyre, Malawi
Camilla Rothe, Derek J. Sloan, Patrick Goodson, Jean Chikafa, Mavuto Mukaka, Brigitte Denis, Tom Harrison, Joep J. van Oosterhout, Robert S. Heyderman, David G. Lalloo, Theresa Allain, Nicholas A. Feasey
High-resolution single nucleotide polymorphism analysis distinguishes recrudescence and re-infection in recurrent invasive non-typhoidal Salmonella Typhimurium disease.
Chinyere K. Okoro, Robert A. Kingsley, Michael A. Quail, Anstead M. Kankwatira, Nicholas A. Feasey, Julian Parkhill, Gordon Dougan, Melita A. Gordon
Invasive non-typhoidal salmonella disease: an emerging and neglected tropical disease in Africa
Nicholas A Feasey, Gordon Dougan, Robert A Kingsley, Robert S Heyderman, Melita A Gordon
Moxifloxacin and pyrazinamide susceptibility testing in a complex case of multidrug-resistant tuberculosis.
Feasey NA, Pond M, Coleman D, Solomon AW, Cosgrove CA, Delgado R, Butcher PD, Mitchison DA, Harrison T.
Review article: the aetiology, investigation and management of diarrhoea in the HIV-positive patient.
Feasey NA, Healey P, Gordon MA.
Are nasal carriers of Staphylococcus aureus more likely to become colonized or infected with methicillin-resistant Staphylococcus aureus on admission to a hospital?
Juliane Krebes, Hasan Al-Ghusein, Nick Feasey, Aodhan Breathnach, Jodi A. Lindsay
Human melioidosis, Malawi, 2011
Thembi Katangwe, Janet Purcell, Naor Bar-Zeev, Brigitte Denis, Jacqui Montgomery, Maaike Alaerts, Robert Simon Heyderman, David A.B. Dance, Neil Kennedy, Nicholas Feasey, Christopher Alan Moxon
Neglected tropical diseases.
Feasey N, Wansbrough-Jones M, Mabey DC, Solomon AW.
Typhoid fever and invasive nontyphoid salmonellosis, Malawi and South Africa
Nicholas A. Feasey, Brett N. Archer, Robert S. Heyderman, Arvinda Sooka, Brigitte Dennis, Melita A. Gordon, Karen H. Keddy
|Three epidemics of Salmonella blood stream infection in Malawi. The 8th International Conference on Typhoid Fever and Other Invasive Salmonelloses, Dhaka, Bangladesh. March 2013.
|Feasey N, Gordon MA: Chapter 52 Salmonella Infections Manson’s Tropical Diseases. Eds Lalloo, White, Farrar. Cambridge. In Press
|Feasey N, Parry C: Typhoid Challenging Concepts in infectious diseases and microbiology: Typhoid Fever. 1st Edition, Eds Arnold, Griffin. Oxford. 2014
|Feasey N, Gordon MA: Chapter 49 Typhoid & Non-typhoid Salmonella Principles of Medicine in Africa. 4th edition, Eds Parry, Mabey, Whitty. Cambridge 2012
|Feasey N, Gordn MA: Chapter 48 Cholera. Principles of Medicine in Africa. 4th edition, Eds Parry, Mabey, Whitty. Cambridge 2012.
|Gordon MA, Feasey N, Graham S. Non-typhoid salmonella infection. Hunter's Tropical Medicine. 9th edition. Eds Magill, Maguire, Ryan, Solomon. Elsevier 2012.