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Dr Nick Feasey


Nick Feasey 250X290

Nick is a medical microbiologist and infectious disease physician, and was based at the Malawi Liverpool Wellcome Trust Laboratory. His undergraduate training was at the Royal Free and he trained in infection medicine at St George’s Hospital in London. Nick's research interests include invasive Salmonella, the evolution of antimicrobial resistance and Cryptococcal meningitis and he was awarded a Research Training Fellowship by the Wellcome Trust in June 2010.

Nick's research in Malawi focused on causes of and outcomes from bloodstream infection (BSI), especially invasive Salmonella disease. The work demonstrated that a fall in BSI of all causes following the roll-out of antiretroviral therapy, especially recurrent Salmonella BSI. Investigation of the genomic epidemiology of Salmonella Enteritidis at WTSI revealed the existence of a novel, African clone of Enteritidis circulating in Africa.

Publications for Nick Feasey

Publication Rapid emergence of multidrug resistant, H58-lineage Salmonella typhi in Blantyre, Malawi.
2015
Feasey NA, Gaskell K, Wong V, Msefula C, Selemani G, Kumwenda S, Allain TJ, Mallewa J, Kennedy N, Bennett A, Nyirongo JO, Nyondo PA, Zulu MD, Parkhill J, Dougan G, Gordon MA, Heyderman RS.


Publication Patterns of Genome Evolution That Have Accompanied Host Adaptation in Salmonella.
2015
Langridge GC, Fookes M, Connor TR, Feltwell T, Feasey N, Parsons BN, Seth-Smith HM, Barquist L, Stedman A, Humphrey T, Wigley P, Peters SE, Maskell DJ, Corander J, Chabalgoity JA, Barrow P, Parkhill J, Dougan G, Thomson NR.


Publication A prospective study of mortality from cryptococcal meningitis following treatment induction with 1200 mg oral fluconazole in Blantyre, Malawi.
2014
Katherine M. Gaskell, Camilla Rothe, Roshina Gnanadurai, Patrick Goodson, Chikondi Jassi, Robert S. Heyderman, Theresa J. Allain, Thomas S. Harrison, David G. Lalloo, Derek J. Sloan, and Nicholas A. Feasey


Publication Drug resistance in Salmonella enterica ser. Typhimurium bloodstream infection, Malawi.
2014
Feasey NA, Cain AK, Msefula CL, Pickard D, Alaerts M, Aslett M, Everett DB, Allain TJ, Dougan G, Gordon MA, Heyderman RS, Kingsley RA.


Publication A reduction in adult blood stream infection and case fatality at a large African hospital following antiretroviral therapy roll-out.
2014
Feasey NA, Houston A, Mukaka M, Komrower D, Mwalukomo T, Tenthani L, Jahn A, Moore M, Peters RP, Gordon MA, Everett DB, French N, van Oosterhout JJ, Allain TJ, Heyderman RS.


Publication Bacterial meningitis in Malawian adults, adolescents, and children during the era of antiretroviral scale-up and Haemophilus influenzae type b vaccination, 2000-2012.
2014
Wall EC, Everett DB, Mukaka M, Bar-Zeev N, Feasey N, Jahn A, Moore M, van Oosterhout JJ, Pensalo P, Baguimira K, Gordon SB, Molyneux EM, Carrol ED, French N, Molyneux ME, Heyderman RS.


Publication Sequential acquisition of T cells and antibodies to nontyphoidal Salmonella in Malawian children.
2014
Nyirenda TS, Gilchrist JJ, Feasey NA, Glennie SJ, Bar-Zeev N, Gordon MA, MacLennan CA, Mandala WL, Heyderman RS.


Publication Sepsis carries a high mortality among hospitalised adults in Malawi in the era of antiretroviral therapy scale-up: A longitudinal cohort study.
2014
Waitt PI, Mukaka M, Goodson P, SimuKonda FD, Waitt CJ, Feasey N, Allain TJ, Downie P, Heyderman RS3


Publication Evaluation of Xpert MTB/RIF for Detection of Tuberculosis from Blood Samples of HIV-Infected Adults Confirms Mycobacterium tuberculosis Bacteremia as an Indicator of Poor Prognosis
2013
Nicholas A. Feasey, Padmapriya P. Banada, William Howson, Derek J. Sloan, Aaron Mdolo, Catharina Boehme, Geoffrey A. Chipungu, Theresa J. Allain, Robert S. Heyderman, Elizabeth L. Corbett, David Alland


Publication A prospective longitudinal study of the clinical outcomes from cryptococcal meningitis following treatment induction with 800 mg oral fluconazole in Blantyre, Malawi
2013
Camilla Rothe, Derek J. Sloan, Patrick Goodson, Jean Chikafa, Mavuto Mukaka, Brigitte Denis, Tom Harrison, Joep J. van Oosterhout, Robert S. Heyderman, David G. Lalloo, Theresa Allain, Nicholas A. Feasey


Publication High-resolution single nucleotide polymorphism analysis distinguishes recrudescence and re-infection in recurrent invasive non-typhoidal Salmonella Typhimurium disease.
2012
Chinyere K. Okoro, Robert A. Kingsley, Michael A. Quail, Anstead M. Kankwatira, Nicholas A. Feasey, Julian Parkhill, Gordon Dougan, Melita A. Gordon


Publication Invasive non-typhoidal salmonella disease: an emerging and neglected tropical disease in Africa
2012
Nicholas A Feasey, Gordon Dougan, Robert A Kingsley, Robert S Heyderman, Melita A Gordon


Publication Moxifloxacin and pyrazinamide susceptibility testing in a complex case of multidrug-resistant tuberculosis.
2011
Feasey NA, Pond M, Coleman D, Solomon AW, Cosgrove CA, Delgado R, Butcher PD, Mitchison DA, Harrison T.


Publication Review article: the aetiology, investigation and management of diarrhoea in the HIV-positive patient.
2011
Feasey NA, Healey P, Gordon MA.


Publication Are nasal carriers of Staphylococcus aureus more likely to become colonized or infected with methicillin-resistant Staphylococcus aureus on admission to a hospital?
2011
Juliane Krebes, Hasan Al-Ghusein, Nick Feasey, Aodhan Breathnach, Jodi A. Lindsay


Publication Human melioidosis, Malawi, 2011
2011
Thembi Katangwe, Janet Purcell, Naor Bar-Zeev, Brigitte Denis, Jacqui Montgomery, Maaike Alaerts, Robert Simon Heyderman, David A.B. Dance, Neil Kennedy, Nicholas Feasey, Christopher Alan Moxon


Publication Neglected tropical diseases.
2010
Feasey N, Wansbrough-Jones M, Mabey DC, Solomon AW.


Publication Typhoid fever and invasive nontyphoid salmonellosis, Malawi and South Africa
2010
Nicholas A. Feasey, Brett N. Archer, Robert S. Heyderman, Arvinda Sooka, Brigitte Dennis, Melita A. Gordon, Karen H. Keddy


 Other presentations:

Three epidemics of Salmonella blood stream infection in Malawi. The 8th International Conference on Typhoid Fever and Other Invasive Salmonelloses, Dhaka, Bangladesh. March 2013.

Book chapters:

Feasey N, Gordon MA: Chapter 52 Salmonella Infections Manson’s Tropical      Diseases. Eds Lalloo, White, Farrar. Cambridge. In Press
Feasey N, Parry C: Typhoid Challenging Concepts in infectious diseases and microbiology: Typhoid Fever. 1st Edition, Eds Arnold, Griffin. Oxford. 2014
Feasey N, Gordon MA: Chapter 49 Typhoid & Non-typhoid Salmonella Principles of Medicine in Africa. 4th edition, Eds Parry, Mabey, Whitty. Cambridge 2012
Feasey N, Gordn MA: Chapter 48 Cholera. Principles of Medicine in Africa. 4th edition, Eds Parry, Mabey, Whitty. Cambridge 2012.
Gordon MA, Feasey N, Graham S. Non-typhoid salmonella infection. Hunter's Tropical Medicine. 9th edition. Eds Magill, Maguire, Ryan, Solomon. Elsevier 2012.